Final Score: Cardinals 15 - 49ers 16
Sunday, September 21, 2025 at 4:25 PM ET
Cardinals @ 49ers
NFL model probabilities, projected margin and matchup analysis
Model Prediction Through Season
| Stat | Cardinals | 49ers |
|---|---|---|
| All-time wins | 28 | 34 |
| Last 5 meetings | 2 | 3 |
| Average points | 20.9 | 23.7 |
| Last meeting | 47 | 24 |
| Stat | Cardinals | 49ers |
|---|---|---|
| Games played | 2 | 2 |
| Avg points scored | 23.5 | 21.5 |
| Avg points conceded | 17.5 | 17.0 |
| Win percentage | 100% | 100% |
| Away win % / Home win % | 100% | - |
Recent Results
Cardinals
vs Carolina Panthers
Sep 14, 2025 · Margin: +5 · Total: 49
27-22
@ New Orleans Saints
Sep 7, 2025 · Margin: +7 · Total: 33
20-13
vs San Francisco 49ers
Jan 5, 2025 · Margin: +23 · Total: 71
47-24
@ Los Angeles Rams
Dec 28, 2024 · Margin: -4 · Total: 22
9-13
@ Carolina Panthers
Dec 22, 2024 · Margin: -6 · Total: 66
30-36
vs New England Patriots
Dec 15, 2024 · Margin: +13 · Total: 47
30-17
vs Seattle Seahawks
Dec 8, 2024 · Margin: -12 · Total: 48
18-30
@ Minnesota Vikings
Dec 1, 2024 · Margin: -1 · Total: 45
22-23
@ Seattle Seahawks
Nov 24, 2024 · Margin: -10 · Total: 22
6-16
vs New York Jets
Nov 10, 2024 · Margin: +25 · Total: 37
31-6
49ers
@ New Orleans Saints
Sep 14, 2025 · Margin: +5 · Total: 47
26-21
@ Seattle Seahawks
Sep 7, 2025 · Margin: +4 · Total: 30
17-13
@ Arizona Cardinals
Jan 5, 2025 · Margin: -23 · Total: 71
24-47
vs Detroit Lions
Dec 30, 2024 · Margin: -6 · Total: 74
34-40
@ Miami Dolphins
Dec 22, 2024 · Margin: -12 · Total: 46
17-29
vs Los Angeles Rams
Dec 12, 2024 · Margin: -6 · Total: 18
6-12
vs Chicago Bears
Dec 8, 2024 · Margin: +25 · Total: 51
38-13
@ Buffalo Bills
Dec 1, 2024 · Margin: -25 · Total: 45
10-35
@ Green Bay Packers
Nov 24, 2024 · Margin: -28 · Total: 48
10-38
vs Seattle Seahawks
Nov 17, 2024 · Margin: -3 · Total: 37
17-20