Final Score: 49ers 41 - Cardinals 22
Sunday, November 16, 2025 at 4:05 PM ET
49ers @ Cardinals
NFL model probabilities, projected margin and matchup analysis
Model Prediction Through Season
| Stat | 49ers | Cardinals |
|---|---|---|
| All-time wins | 35 | 28 |
| Last 5 meetings | 3 | 2 |
| Average points | 23.6 | 20.8 |
| Last meeting | 16 | 15 |
| Stat | 49ers | Cardinals |
|---|---|---|
| Games played | 10 | 9 |
| Avg points scored | 22.0 | 22.4 |
| Avg points conceded | 23.0 | 23.9 |
| Win percentage | 60% | 33% |
| Away win % / Home win % | 67% | 25% |
Recent Results
49ers
vs Los Angeles Rams
Nov 9, 2025 · Margin: -16 · Total: 68
26-42
@ New York Giants
Nov 2, 2025 · Margin: +10 · Total: 58
34-24
@ Houston Texans
Oct 26, 2025 · Margin: -11 · Total: 41
15-26
vs Atlanta Falcons
Oct 19, 2025 · Margin: +10 · Total: 30
20-10
@ Tampa Bay Buccaneers
Oct 12, 2025 · Margin: -11 · Total: 49
19-30
@ Los Angeles Rams
Oct 2, 2025 · Margin: +3 · Total: 49
26-23
vs Jacksonville Jaguars
Sep 28, 2025 · Margin: -5 · Total: 47
21-26
vs Arizona Cardinals
Sep 21, 2025 · Margin: +1 · Total: 31
16-15
@ New Orleans Saints
Sep 14, 2025 · Margin: +5 · Total: 47
26-21
@ Seattle Seahawks
Sep 7, 2025 · Margin: +4 · Total: 30
17-13
Cardinals
@ Seattle Seahawks
Nov 9, 2025 · Margin: -22 · Total: 66
22-44
@ Dallas Cowboys
Nov 3, 2025 · Margin: +10 · Total: 44
27-17
vs Green Bay Packers
Oct 19, 2025 · Margin: -4 · Total: 50
23-27
@ Indianapolis Colts
Oct 12, 2025 · Margin: -4 · Total: 58
27-31
vs Tennessee Titans
Oct 5, 2025 · Margin: -1 · Total: 43
21-22
vs Seattle Seahawks
Sep 25, 2025 · Margin: -3 · Total: 43
20-23
@ San Francisco 49ers
Sep 21, 2025 · Margin: -1 · Total: 31
15-16
vs Carolina Panthers
Sep 14, 2025 · Margin: +5 · Total: 49
27-22
@ New Orleans Saints
Sep 7, 2025 · Margin: +7 · Total: 33
20-13
vs San Francisco 49ers
Jan 5, 2025 · Margin: +23 · Total: 71
47-24