| Date | Matchup | Result | Winner | Model Projection | Stage |
|---|---|---|---|---|---|
| Sep 26, 2021 | 30–28 | Packers +2 | Packers +0.6 | Regular Season | |
| Sep 26, 2021 | 24–34 | Rams +10 | Rams +1.2 | Regular Season | |
| Sep 26, 2021 | 17–30 | Vikings +13 | Seahawks +1.8 | Regular Season | |
| Sep 26, 2021 | 0–26 | Broncos +26 | Broncos +8.8 | Regular Season | |
| Sep 26, 2021 | 28–31 | Raiders +3 | Raiders +4.3 | Regular Season | |
| Sep 26, 2021 | 31–19 | Cardinals +12 | Cardinals +6.1 | Regular Season | |
| Sep 26, 2021 | 17–14 | Falcons +3 | Giants +1.0 | Regular Season | |
| Sep 26, 2021 | 19–17 | Ravens +2 | Ravens +6.9 | Regular Season | |
| Sep 26, 2021 | 21–43 | Bills +22 | Bills +10.9 | Regular Season | |
| Sep 26, 2021 | 6–26 | Browns +20 | Browns +3.5 | Regular Season | |
| Sep 26, 2021 | 24–10 | Bengals +14 | Steelers +8.7 | Regular Season | |
| Sep 26, 2021 | 16–25 | Titans +9 | Titans +4.6 | Regular Season | |
| Sep 26, 2021 | 30–24 | Chargers +6 | Chiefs +10.1 | Regular Season | |
| Sep 26, 2021 | 28–13 | Saints +15 | Saints +1.6 | Regular Season |