| Date | Matchup | Result | Winner | Model Projection | Stage |
|---|---|---|---|---|---|
| Oct 3, 2021 | 19–17 | Buccaneers +2 | Buccaneers +2.2 | Regular Season | |
| Oct 3, 2021 | 23–7 | Ravens +16 | Ravens +2.4 | Regular Season | |
| Oct 3, 2021 | 17–27 | Packers +10 | Packers +8.1 | Regular Season | |
| Oct 3, 2021 | 37–20 | Cardinals +17 | Rams +7.4 | Regular Season | |
| Oct 3, 2021 | 28–21 | Seahawks +7 | 49ers +2.0 | Regular Season | |
| Oct 3, 2021 | 34–30 | Commanders +4 | Falcons +4.2 | Regular Season | |
| Oct 3, 2021 | 0–40 | Bills +40 | Bills +12.5 | Regular Season | |
| Oct 3, 2021 | 28–36 | Cowboys +8 | Cowboys +2.7 | Regular Season | |
| Oct 3, 2021 | 14–24 | Bears +10 | Bears +8.1 | Regular Season | |
| Oct 3, 2021 | 14–7 | Browns +7 | Vikings +2.1 | Regular Season | |
| Oct 3, 2021 | 27–17 | Colts +10 | Dolphins +2.5 | Regular Season | |
| Oct 3, 2021 | 42–30 | Chiefs +12 | Chiefs +5.8 | Regular Season | |
| Oct 3, 2021 | 27–21 | Giants +6 | Saints +14.1 | Regular Season | |
| Oct 3, 2021 | 24–27 | Jets +3 | Titans +6.6 | Regular Season |