| Date | Matchup | Result | Winner | Model Projection | Stage |
|---|---|---|---|---|---|
| Oct 10, 2021 | 38–20 | Bills +18 | Chiefs +2.7 | Regular Season | |
| Oct 10, 2021 | 10–17 | Cardinals +7 | Cardinals +5.6 | Regular Season | |
| Oct 10, 2021 | 20–44 | Cowboys +24 | Cowboys +7.8 | Regular Season | |
| Oct 10, 2021 | 20–9 | Bears +11 | Raiders +4.4 | Regular Season | |
| Oct 10, 2021 | 42–47 | Chargers +5 | Chargers +2.1 | Regular Season | |
| Oct 10, 2021 | 21–18 | Eagles +3 | Panthers +5.4 | Regular Season | |
| Oct 10, 2021 | 25–22 | Packers +3 | Packers +5.4 | Regular Season | |
| Oct 10, 2021 | 19–27 | Steelers +8 | Steelers +4.2 | Regular Season | |
| Oct 10, 2021 | 17–19 | Vikings +2 | Vikings +9.2 | Regular Season | |
| Oct 10, 2021 | 25–22 | Patriots +3 | Patriots +1.4 | Regular Season | |
| Oct 10, 2021 | 37–19 | Titans +18 | Titans +7.2 | Regular Season | |
| Oct 10, 2021 | 17–45 | Buccaneers +28 | Buccaneers +10.4 | Regular Season | |
| Oct 10, 2021 | 33–22 | Saints +11 | Saints +4.1 | Regular Season | |
| Oct 10, 2021 | 27–20 | Falcons +7 | Falcons +4.8 | Regular Season |