| Date | Matchup | Result | Winner | Model Projection | Stage |
|---|---|---|---|---|---|
| Oct 17, 2021 | 20–23 | Steelers +3 | Steelers +2.0 | Regular Season | |
| Oct 17, 2021 | 35–29 | Cowboys +6 | Patriots +2.7 | Regular Season | |
| Oct 17, 2021 | 34–24 | Raiders +10 | Broncos +2.7 | Regular Season | |
| Oct 17, 2021 | 37–14 | Cardinals +23 | Browns +2.4 | Regular Season | |
| Oct 17, 2021 | 6–34 | Ravens +28 | Ravens +7.1 | Regular Season | |
| Oct 17, 2021 | 34–28 | Vikings +6 | Panthers +2.1 | Regular Season | |
| Oct 17, 2021 | 24–14 | Packers +10 | Packers +2.2 | Regular Season | |
| Oct 17, 2021 | 34–11 | Bengals +23 | Bengals +0.6 | Regular Season | |
| Oct 17, 2021 | 3–31 | Colts +28 | Colts +8.1 | Regular Season | |
| Oct 17, 2021 | 31–13 | Chiefs +18 | Chiefs +4.9 | Regular Season | |
| Oct 17, 2021 | 38–11 | Rams +27 | Rams +6.5 | Regular Season | |
| Oct 17, 2021 | 23–20 | Jaguars +3 | Dolphins +6.5 | Regular Season |