| Date | Matchup | Result | Winner | Model Projection | Stage |
|---|---|---|---|---|---|
| Nov 7, 2021 | 28–16 | Titans +12 | Rams +3.8 | Regular Season | |
| Nov 7, 2021 | 31–17 | Cardinals +14 | Cardinals +2.1 | Regular Season | |
| Nov 7, 2021 | 7–13 | Chiefs +6 | Chiefs +0.1 | Regular Season | |
| Nov 7, 2021 | 27–24 | Chargers +3 | Chargers +0.3 | Regular Season | |
| Nov 7, 2021 | 27–25 | Falcons +2 | Saints +11.9 | Regular Season | |
| Nov 7, 2021 | 31–34 | Ravens +3 | Ravens +7.9 | Regular Season | |
| Nov 7, 2021 | 6–9 | Jaguars +3 | Bills +12.5 | Regular Season | |
| Nov 7, 2021 | 24–6 | Patriots +18 | Patriots +0.3 | Regular Season | |
| Nov 7, 2021 | 41–16 | Browns +25 | Bengals +2.2 | Regular Season | |
| Nov 7, 2021 | 30–16 | Broncos +14 | Cowboys +7.8 | Regular Season | |
| Nov 7, 2021 | 9–17 | Dolphins +8 | Dolphins +5.5 | Regular Season | |
| Nov 7, 2021 | 16–23 | Giants +7 | Raiders +2.4 | Regular Season |