| Date | Matchup | Result | Winner | Model Projection | Stage |
|---|---|---|---|---|---|
| Nov 21, 2021 | 37–41 | Chargers +4 | Chargers +2.1 | Regular Season | |
| Nov 21, 2021 | 23–13 | Cardinals +10 | Seahawks +2.0 | Regular Season | |
| Nov 21, 2021 | 9–19 | Chiefs +10 | Chiefs +7.9 | Regular Season | |
| Nov 21, 2021 | 32–13 | Bengals +19 | Raiders +4.6 | Regular Season | |
| Nov 21, 2021 | 16–13 | Ravens +3 | Ravens +2.2 | Regular Season | |
| Nov 21, 2021 | 41–15 | Colts +26 | Bills +7.8 | Regular Season | |
| Nov 21, 2021 | 27–21 | Commanders +6 | Panthers +3.6 | Regular Season | |
| Nov 21, 2021 | 10–13 | Browns +3 | Browns +11.9 | Regular Season | |
| Nov 21, 2021 | 31–34 | Vikings +3 | Packers +4.4 | Regular Season | |
| Nov 21, 2021 | 22–13 | Texans +9 | Titans +14.9 | Regular Season | |
| Nov 21, 2021 | 30–10 | 49ers +20 | 49ers +5.8 | Regular Season | |
| Nov 21, 2021 | 24–17 | Dolphins +7 | Dolphins +4.0 | Regular Season | |
| Nov 21, 2021 | 29–40 | Eagles +11 | Saints +4.1 | Regular Season |