| Date | Matchup | Result | Winner | Model Projection | Stage |
|---|---|---|---|---|---|
| Nov 28, 2021 | 10–16 | Ravens +6 | Ravens +5.5 | Regular Season | |
| Nov 28, 2021 | 28–36 | Packers +8 | Packers +5.0 | Regular Season | |
| Nov 28, 2021 | 26–34 | 49ers +8 | 49ers +2.7 | Regular Season | |
| Nov 28, 2021 | 13–28 | Broncos +15 | Chargers +0.3 | Regular Season | |
| Nov 28, 2021 | 21–14 | Falcons +7 | Falcons +2.4 | Regular Season | |
| Nov 28, 2021 | 10–33 | Dolphins +23 | Dolphins +3.6 | Regular Season | |
| Nov 28, 2021 | 10–41 | Bengals +31 | Bengals +2.0 | Regular Season | |
| Nov 28, 2021 | 21–14 | Jets +7 | Texans +6.0 | Regular Season | |
| Nov 28, 2021 | 38–31 | Buccaneers +7 | Colts +2.0 | Regular Season | |
| Nov 28, 2021 | 13–36 | Patriots +23 | Patriots +2.7 | Regular Season | |
| Nov 28, 2021 | 7–13 | Giants +6 | Eagles +0.3 | Regular Season |