| Date | Matchup | Result | Winner | Model Projection | Stage |
|---|---|---|---|---|---|
| Dec 5, 2021 | 9–22 | Chiefs +13 | Chiefs +10.6 | Regular Season | |
| Dec 5, 2021 | 19–20 | Steelers +1 | Ravens +2.2 | Regular Season | |
| Dec 5, 2021 | 7–37 | Rams +30 | Rams +15.8 | Regular Season | |
| Dec 5, 2021 | 17–15 | Commanders +2 | Raiders +2.7 | Regular Season | |
| Dec 5, 2021 | 23–30 | Seahawks +7 | Seahawks +2.1 | Regular Season | |
| Dec 5, 2021 | 33–22 | Cardinals +11 | Cardinals +3.0 | Regular Season | |
| Dec 5, 2021 | 30–17 | Buccaneers +13 | Buccaneers +6.6 | Regular Season | |
| Dec 5, 2021 | 41–22 | Chargers +19 | Bengals +4.6 | Regular Season | |
| Dec 5, 2021 | 27–29 | Lions +2 | Vikings +6.5 | Regular Season | |
| Dec 5, 2021 | 31–0 | Colts +31 | Colts +6.3 | Regular Season | |
| Dec 5, 2021 | 9–20 | Dolphins +11 | Dolphins +5.0 | Regular Season | |
| Dec 5, 2021 | 33–18 | Eagles +15 | Eagles +3.4 | Regular Season |