Records since the 1970 season.
| Matchup | Record | Win % | Vs Expected | Games |
|---|---|---|---|---|
| Bills Dolphins | 57-60-2 | 48.7% | +2.3 | 119 |
| Bills Patriots | 44-68-2 | 39.3% | -7.3 | 114 |
| Bills Jets | 62-49-2 | 55.9% | +0.0 | 113 |
| Bills Colts | 39-33-1 | 54.2% | -0.5 | 73 |
| Bills Chiefs | 22-17-1 | 56.4% | +3.7 | 40 |
| Bills Bengals | 17-16 | 51.5% | +0.2 | 33 |
| Bills Steelers | 14-17 | 45.2% | -0.0 | 31 |
| Bills Titans | 14-17 | 45.2% | -2.2 | 31 |
| Bills Broncos | 13-13-1 | 50.0% | -0.2 | 27 |
| Bills Raiders | 13-12-1 | 52.0% | -1.4 | 26 |
| Bills Browns | 11-13 | 45.8% | -1.2 | 24 |
| Bills Chargers | 7-15-1 | 31.8% | -3.2 | 23 |
| Bills Jaguars | 11-10 | 52.4% | -0.8 | 21 |
| Bills Commanders | 11-6 | 64.7% | +2.5 | 17 |
| Bills Vikings | 6-9-1 | 40.0% | -1.3 | 16 |
| Bills Rams | 9-6-1 | 60.0% | +0.3 | 16 |
| Bills Eagles | 6-10 | 37.5% | -1.7 | 16 |
| Bills Giants | 8-7 | 53.3% | +0.2 | 15 |
| Bills Bears | 6-8-1 | 42.9% | -2.1 | 15 |
| Bills Seahawks | 7-8 | 46.7% | +0.1 | 15 |
| Bills Ravens | 7-7-1 | 50.0% | +0.3 | 15 |
| Bills Packers | 9-5-1 | 64.3% | +1.5 | 15 |
| Bills Buccaneers | 6-8 | 42.9% | -2.0 | 14 |
| Bills Texans | 5-8-1 | 38.5% | -2.6 | 14 |
| Bills 49ers | 8-6 | 57.1% | +1.7 | 14 |
| Bills Lions | 8-4-2 | 66.7% | +0.4 | 14 |
| Bills Cowboys | 6-8 | 42.9% | +0.8 | 14 |
| Bills Falcons | 6-8 | 42.9% | -1.4 | 14 |
| Bills Saints | 6-7 | 46.2% | -0.8 | 13 |
| Bills Cardinals | 8-5 | 61.5% | +1.1 | 13 |
| Bills Panthers | 7-2 | 77.8% | +2.2 | 9 |
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