| Date | Matchup | Result | Winner | Model Projection | Stage |
|---|---|---|---|---|---|
| May 21, 2006 | 3–4 | Mets +1 | Yankees +0.4 | Regular Season | |
| May 21, 2006 | 2–1 | Braves +1 | Braves +0.3 | Regular Season | |
| May 21, 2006 | 0–7 | Dodgers +7 | Angels +0.1 | Regular Season | |
| May 21, 2006 | 6–0 | Giants +6 | Athletics +0.6 | Regular Season | |
| May 21, 2006 | 8–10 | Mariners +2 | Padres +0.1 | Regular Season | |
| May 21, 2006 | 3–5 | Rockies +2 | Blue Jays +0.1 | Regular Season | |
| May 21, 2006 | 10–3 | Cardinals +7 | Cardinals +1.6 | Regular Season | |
| May 21, 2006 | 7–4 | Cubs +3 | White Sox +1.1 | Regular Season | |
| May 21, 2006 | 0–5 | Astros +5 | Astros +0.5 | Regular Season | |
| May 21, 2006 | 3–5 | Brewers +2 | Brewers +0.0 | Regular Season | |
| May 21, 2006 | 5–10 | Phillies +5 | Red Sox +0.2 | Regular Season | |
| May 21, 2006 | 0–3 | Rays +3 | Rays +0.0 | Regular Season | |
| May 21, 2006 | 1–3 | Nationals +2 | Nationals +0.2 | Regular Season | |
| May 21, 2006 | 0–1 | Tigers +1 | Tigers +0.1 | Regular Season | |
| May 21, 2006 | 2–3 | Guardians +1 | Guardians +1.0 | Regular Season |