Records since the 1969 season.
| Matchup | Record | Win % | Vs Expected | Games |
|---|---|---|---|---|
| Red Sox Yankees | 451-476 | 48.7% | +5.0 | 886 |
| Red Sox Orioles | 495-397 | 55.5% | +19.8 | 839 |
| Red Sox Blue Jays | 406-348 | 53.8% | +1.6 | 728 |
| Red Sox Guardians | 347-295-3 | 54.0% | -2.3 | 601 |
| Red Sox Tigers | 350-270 | 56.5% | +14.3 | 594 |
| Red Sox Athletics | 322-260 | 55.3% | +18.3 | 567 |
| Red Sox Angels | 314-260 | 54.7% | +8.7 | 560 |
| Red Sox Rangers | 297-271 | 52.3% | -12.4 | 547 |
| Red Sox White Sox | 284-252-1 | 53.0% | -7.7 | 513 |
| Red Sox Twins | 279-246 | 53.1% | -5.5 | 504 |
| Red Sox Royals | 271-250 | 52.0% | -13.5 | 496 |
| Red Sox Rays | 272-235 | 53.6% | -4.8 | 486 |
| Red Sox Mariners | 269-199 | 57.5% | +8.6 | 460 |
| Red Sox Brewers | 225-199 | 53.1% | -5.2 | 393 |
| Red Sox Astros | 54-55 | 49.5% | -1.6 | 104 |
| Red Sox Braves | 55-51 | 51.9% | +2.9 | 100 |
| Red Sox Phillies | 54-39 | 58.1% | +4.0 | 90 |
| Red Sox Marlins | 38-18 | 67.9% | +5.7 | 54 |
| Red Sox Mets | 31-23 | 57.4% | +3.2 | 52 |
| Red Sox Nationals | 30-18 | 62.5% | +2.8 | 46 |
| Red Sox Cardinals | 24-17 | 58.5% | +3.2 | 38 |
| Red Sox Rockies | 23-16 | 59.0% | -0.2 | 37 |
| Red Sox Reds | 23-13 | 63.9% | +3.7 | 34 |
| Red Sox Dodgers | 19-16 | 54.3% | +2.2 | 33 |
| Red Sox Diamondbacks | 18-15 | 54.5% | -0.5 | 31 |
| Red Sox Padres | 19-14 | 57.6% | +0.9 | 31 |
| Red Sox Giants | 19-12 | 61.3% | +2.5 | 29 |
| Red Sox Cubs | 13-14-3 | 48.1% | -3.2 | 28 |
| Red Sox Pirates | 15-15 | 50.0% | -2.2 | 27 |
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