Records since the 1969 season.
| Matchup | Record | Win % | Vs Expected | Games |
|---|---|---|---|---|
| Mariners Rangers | 395-379 | 51.0% | +16.4 | 751 |
| Mariners Angels | 355-408-4 | 46.5% | -13.2 | 748 |
| Mariners Athletics | 365-396 | 48.0% | +0.7 | 741 |
| Mariners Twins | 253-241-1 | 51.2% | +9.7 | 486 |
| Mariners Royals | 242-250 | 49.2% | +1.8 | 479 |
| Mariners White Sox | 235-255 | 48.0% | -1.5 | 478 |
| Mariners Yankees | 202-279 | 42.0% | -2.5 | 473 |
| Mariners Red Sox | 199-269 | 42.5% | -8.6 | 460 |
| Mariners Orioles | 217-250 | 46.5% | -8.5 | 454 |
| Mariners Guardians | 210-254 | 45.3% | -13.2 | 453 |
| Mariners Tigers | 220-240-1 | 47.8% | -6.3 | 448 |
| Mariners Blue Jays | 216-236 | 47.8% | -0.5 | 444 |
| Mariners Brewers | 122-132 | 48.0% | +5.9 | 249 |
| Mariners Astros | 106-137-2 | 43.6% | -11.2 | 233 |
| Mariners Rays | 119-100 | 54.3% | +6.8 | 214 |
| Mariners Padres | 73-70 | 51.0% | -0.7 | 137 |
| Mariners Rockies | 36-27 | 57.1% | +1.1 | 59 |
| Mariners Giants | 26-26 | 50.0% | -0.4 | 50 |
| Mariners Dodgers | 17-34 | 33.3% | -5.9 | 49 |
| Mariners Diamondbacks | 29-19 | 60.4% | +4.1 | 46 |
| Mariners Nationals | 13-24 | 35.1% | -7.5 | 34 |
| Mariners Phillies | 16-15 | 51.6% | +0.3 | 29 |
| Mariners Braves | 18-13 | 58.1% | +3.2 | 29 |
| Mariners Cubs | 12-19 | 38.7% | -4.0 | 29 |
| Mariners Cardinals | 17-13 | 56.7% | +2.4 | 28 |
| Mariners Marlins | 13-17 | 43.3% | -2.8 | 28 |
| Mariners Reds | 22-8 | 73.3% | +5.8 | 28 |
| Mariners Pirates | 18-11 | 62.1% | +2.5 | 27 |
| Mariners Mets | 19-11 | 63.3% | +3.2 | 27 |
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