@ 49ers
4-4
@ Bills
2-4
Playoffs
0-0
VS EXPECTED
49ers -1.7
Avg Points
21.6-21.6
Most Recent Winner
Bills 10-35
Head-To-Head Margin (Max Last 150 Matches)
| Date | Matchup | Result | Winner | Model Projection | Stage |
|---|---|---|---|---|---|
| Dec 1, 2024 | 10–35 | Buffalo Bills +25 | Buffalo Bills +7.6 | Regular | |
| Dec 7, 2020 | 34–24 | Buffalo Bills +10 | San Francisco 49ers +2.7 | Regular | |
| Oct 16, 2016 | 16–45 | Buffalo Bills +29 | Buffalo Bills +9.3 | Regular | |
| Oct 7, 2012 | 3–45 | San Francisco 49ers +42 | San Francisco 49ers +10.0 | Regular | |
| Nov 30, 2008 | 10–3 | San Francisco 49ers +7 | Buffalo Bills +8.6 | Regular | |
| Dec 26, 2004 | 41–7 | Buffalo Bills +34 | Buffalo Bills +6.6 | Regular | |
| Dec 2, 2001 | 0–35 | San Francisco 49ers +35 | San Francisco 49ers +8.7 | Regular | |
| Oct 4, 1998 | 21–26 | Buffalo Bills +5 | San Francisco 49ers +6.6 | Regular | |
| Dec 3, 1995 | 17–27 | San Francisco 49ers +10 | San Francisco 49ers +11.0 | Regular | |
| Sep 13, 1992 | 34–31 | Buffalo Bills +3 | San Francisco 49ers +3.8 | Regular | |
| Dec 17, 1989 | 10–21 | San Francisco 49ers +11 | San Francisco 49ers +9.9 | Regular | |
| Dec 11, 1983 | 23–10 | San Francisco 49ers +13 | Buffalo Bills +0.4 | Regular | |
| Dec 21, 1980 | 18–13 | Buffalo Bills +5 | Buffalo Bills +4.2 | Regular | |
| Sep 24, 1972 | 20–27 | Buffalo Bills +7 | San Francisco 49ers +7.0 | Regular |