Records since the 1976 season.
| Matchup | Record | Win % | Vs Expected | Games |
|---|---|---|---|---|
| Cavaliers Celtics | 108-150-3 | 41.9% | -4.1 | 261 |
| Cavaliers Bulls | 118-138-4 | 46.1% | -10.2 | 260 |
| Cavaliers Pistons | 121-132-4 | 47.8% | -4.3 | 257 |
| Cavaliers Pacers | 118-121-4 | 49.4% | -4.1 | 243 |
| Cavaliers Wizards | 133-103-3 | 56.4% | +3.8 | 239 |
| Cavaliers Hawks | 115-117-4 | 49.6% | -2.8 | 236 |
| Cavaliers Knicks | 109-116-4 | 48.4% | -1.6 | 229 |
| Cavaliers Bucks | 106-115-4 | 48.0% | -2.5 | 225 |
| Cavaliers Nets | 127-91-4 | 58.3% | -2.8 | 222 |
| Cavaliers 76ers | 100-113-3 | 46.9% | +0.7 | 216 |
| Cavaliers Magic | 76-70-3 | 52.1% | -4.9 | 149 |
| Cavaliers Heat | 59-82-3 | 41.8% | -12.1 | 144 |
| Cavaliers Raptors | 76-59-4 | 56.3% | +1.2 | 139 |
| Cavaliers Hornets | 82-52-3 | 61.2% | +1.6 | 137 |
| Cavaliers Warriors | 60-68-2 | 46.9% | -1.2 | 130 |
| Cavaliers Spurs | 43-70-2 | 38.1% | -1.5 | 115 |
| Cavaliers Rockets | 37-76-2 | 32.7% | -15.7 | 115 |
| Cavaliers Jazz | 49-62-2 | 44.1% | -5.5 | 113 |
| Cavaliers Clippers | 65-43-2 | 60.2% | +5.5 | 110 |
| Cavaliers Thunder | 46-61-2 | 43.0% | +0.1 | 109 |
| Cavaliers Lakers | 49-58-2 | 45.8% | +5.0 | 109 |
| Cavaliers Trail Blazers | 49-57-2 | 46.2% | +2.6 | 108 |
| Cavaliers Kings | 57-48-2 | 54.3% | -3.9 | 107 |
| Cavaliers Suns | 48-57-2 | 45.7% | +1.4 | 107 |
| Cavaliers Nuggets | 48-54-2 | 47.1% | +0.2 | 104 |
| Cavaliers Mavericks | 48-41-2 | 53.9% | +4.4 | 91 |
| Cavaliers Timberwolves | 43-28-2 | 60.6% | +0.5 | 73 |
| Cavaliers Grizzlies | 38-21-2 | 64.4% | +3.5 | 61 |
| Cavaliers Pelicans | 25-26-2 | 49.0% | -1.9 | 53 |
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